Introduction: The key component in this kit is horseradish peroxidase (HRP) polymer (PolyHRP) labeled mouse anti-human cytokeratin 8/18 antibody (clones C94). The product has developed based on using Novodiax’s proprietary enzyme polymerization technology and Direct IHC technology called ihcDirect (Patent Pending) and is optimized for IHC on frozen tissues. The incubation time on frozen tissues is 3 minutes and on FFPE tissues 15-30 minutes.
Monoclonal antibody clone 94 reacts with human cytokeratin intermediate low molecular weight filament proteins of 52.5 kD and 45 kD, i.e., cytokeratins 8 and 18, respectively. Cytokeratins 8 and 18 are expressed in most simple and glandular epithelium, such as thyroid, female breast, gastrointestinal tract, and respiratory tract. In cancer tissues, adenocarcinomas and most non-keratinizing squamous carcinomas express these proteins, but keratinizing squamous carcinomas do not. Antibodies to CK8 and CK18 may be utilized in the classification of tumors of epithelial origin.
ihcDirect® CK 8/18 (Mouse monoclonal antibody Clone C94)
- Catalog Number: RK41001
- Availability: In Stock
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